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Lightweight Federated Learning Frameworks for Privacy-Preserving Predictive Analytics in Remote Patient Monitoring: A Systematic Review

DOI : 10.17577/IJERTV15IS070457
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Lightweight Federated Learning Frameworks for Privacy-Preserving Predictive Analytics in Remote Patient Monitoring: A Systematic Review

D. Sucharitha (1) and Dr. M. Senthil Kumaran (2)

(1) Research Scholar, (2) Associate Professor Department of Computer Science and Engineering

Sri Chandrasekharendra Saraswathi Viswa Mahavidyalaya (SCSVMV) Deemed to be University Kanchipuram, India

Abstract – Remote patient monitoring (RPM) via Internet of Healthcare Things (IoHT) devices creates a tension between the clinical value of continuous physiological data and the imperative to protect patient privacy. Federated learning (FL) resolves this by enabling collaborative model training without centralising raw data, yet most existing FL frameworks are too resource-intensive for wearable and edge hardware. This paper presents a systematic review of 28 studies (20222026), selected from 257 records following PRISMA 2020 guidelines, at the intersection of lightweight FL, privacy preservation, and RPM. We introduce a three-dimensional definition of lightweight covering client model size (MS), communication cost (CC), and device energy consumption (EC), and apply it to score ten representative frameworks. A dedicated privacyaccuracy trade-off analysis reveals that no study reports AUC, sensitivity, and specificity alongside an explicit differential privacy budget (), a critical gap for clinical deployment. We propose a four-component framework- compressed client models, tunable differential privacy, lightweight integrity protection, and hardware-realistic validation-supported by a pseudocode algorithm and architecture diagram. Eight research gaps are identified, with client-side model compression and standardised privacyutility reporting identified as the highest priorities.

Keywords – Federated Learning; Remote Patient Monitoring; IoHT; Lightweight Edge AI; Differential Privacy; PrivacyAccuracy Trade-off; PRISMA; Systematic Review.

  1. INTRODUCTION

    The Internet of Healthcare Things (IoHT) has transformed remote patient monitoring (RPM) from episodic clinic visits into a continuous, data-intensive discipline. Wearable sensors and implanted devices now generate cardiac rhythms, blood glucose, blood pressure, and EEG signals at unprecedented scale [1]. This physiological stream enables predictive analytics for early detection of cardiac events, sepsis, and chronic disease deterioration, yet simultaneously concentrates highly sensitive data subject to HIPAA and GDPR [18].

    The conventional centralised approach-aggregating raw patient data on a cloud server-introduces two structural problems: (i) transferring raw physiology off-device expands the attack surface and triggers regulatory requirements [2, 3]; and (ii) cloud round- trip latency is incompatible with real-time RPM services such as arrhythmia detection [5].

    Federated learning (FL), introduced by McMahan et al. [29], enables multiple distributed clients to train a shared model by exchanging only model updates, never raw data [6, 7]. Foundational advances established formal convergence guarantees [30], healthcare applicability [31], and characterised heterogeneous-hardware challenges [32]. However, the healthcare FL literature has prioritised accuracy and privacy over deployability on constrained hardware. Many reviewed frameworks run client computation on cloud-hosted simulators rather than physical wearables [8, 9].

    This review covers 20222026 because lightweight IoHT-specific FL-applying model compression, quantisation, and on-device training to wearable hardware-only emerged as a systematic research focus after 2021. Earlier foundational work is covered by [29 32]; the present review explicitly characterises itself as a survey of recent developments.

    A. Definition of “Lightweight”

    To resolve terminological ambiguity across the corpus, we adopt a three-dimensional operational definition. A FL framework is classified as lightweight only if it reduces resource demands on one or more of: (MS) Client model size-parameter count or storage footprint reduced via pruning, quantisation, or distillation; (CC) Communication cost-gradient volume per round reduced via compression or sparsification; (EC) Device energy consumption-measurable energy reduction measured on physical constrained

    hardware. Frameworks achieving efficiency solely by offloading computation to a fog or cloud server do NOT qualify as lightweight under this definition, as the client-resident model is unchanged. Table III scores all ten representative frameworks against MS, CC, and EC explicitly.

  2. LITERATURE REVIEW METHODOLOGY

    1. Search Strategy

      Records were retrieved from multiple open-access bibliographic repositories using the query “Lightweight Federated Learning Framework for Privacy-Preserving Predictive Analytics in Remote Patient Monitoring (IoHT)”, restricted to 20222026. This returned 257 records spanning IEEE, Springer, MDPI, Elsevier, Nature, and arXiv. The search was conducted in accordance with PRISMA 2020 guidelines [33].

      TABLE I

      SEARCH CORPUS COMPOSITION

      Attribute

      Value

      Notes

      Database

      Multiple open-access journals

      IEEE, Springer, MDPI, Elsevier, Nature, arXiv

      Records retrieved

      257

      Open access only, 20222026

      Year range

      20222026

      87 records in 2025 (rapid growth)

      Top venues

      IEEE Access; Scientific Reports; arXiv

      Mix of conference and journal

    2. Screening and Eligibility

    After removing 3 duplicates, 254 unique records were screened at title-and-abstract level against two inclusion criteria: (i) explicit treatment of federated, collaborative, or decentralised learning; and (ii) explicit relevance to health, clinical, or IoHT/IoMT contexts. Records failing either criterion were excluded (n = 222). Full-text review of the remaining 32 records excluded 4 further entries (front-matter or off-topic). The final synthesis corpus comprised 28 studies. The PRISMA 2020 screening flow is shown in Fig. 1.

  3. RESULTS AND DISCUSSION

    1. Publication Trend

      The 28 included studies are concentrated in 20252026: 1 (2022), 4 (2023), 4 (2024), 14 (2025), 5 (2026) as shown in Fig. 2. Nineteen of 28 studies (68%) were published in 20252026, confirming that lightweight IoHT-specific FL is a rapidly accelerating research focus and validating the 20222026 scope.

      Fig. 2. Year-wise distribution of included studies (20222026).

    2. Thematic Taxonomy

      Thematic analysis identified five clusters (Table II, Fig. 3): blockchainfederated integration, FL-based security and intrusion detection, privacy-preservation techniques, lightweight and edge-efficient architectures, and general FL/IoHT surveys. Each cluster contains five or six studies, indicating broadly distributed research attention.

      TABLE II

      THEMATIC AND METHODOLOGICAL TAXONOMY

      Thematic Cluster

      Research Focus

      Key Studies

      Methodological Emphasis

      BlockchainFL Integration

      Decentralised trust and incentive layers with FL

      [3],[7],[9],[10],[11]

      Consensus protocols, smart contracts

      FL-Based Security & IDS

      FL to detect poisoning, inference, network attacks

      [12],[13],[14],[15],[16]

      Federated classifiers, graph learning

      Privacy-Preservation

      DP, secure aggregation, robust aggregation

      [2],[17],[18],[19],[20]

      Formal privacy guarantees, robustness

      Lightweight / Edge

      Fog/edge offloading, lightweight authentication

      [5],[8],[21],[22],[23],[24]

      Edge computation, lightweight protocols

      General FL/IoHT Surveys

      Broad FL application and IoHT convergence surveys

      [1],[6],[25],[26],[27],[28]

      Narrative and systematic survey methods

      Fig. 3. Thematic cluster distribution of included studies (n = 28).

    3. Comparative Framework Analysis

      Ten representative frameworks were compared across privacy mechanism, efficiency strategy, lightweight criteria (MS/CC/EC), validation dataset, and key limitation (Table III). Validation data type: R = real clinical; Sy = synthetic; Si = simulation; N = no validation.

      TABLE III

      COMPARATIVE EVALUATION OF TEN REPRESENTATIVE FL FRAMEWORKS

      Ref.

      Framework

      Focus

      Privacy

      Mechanism

      Lightweight

      Strategy

      MS

      CC

      EC

      Validation

      Dataset

      Type

      Key

      Limitation

      [21]

      Edge-based secure health monitoring

      Edge encryption before cloud

      Fog layer offloading

      x

      x

      x

      Simulated edge-node scenarios

      Si

      No client- model compression

      [3]

      Blockchain- RL FL for IoMT

      (COVID-19)

      Blockchain- anchored updates; RL

      Distributed computation

      x

      P

      x

      COVID-19

      dataset (simulated partition)

      R/Si

      Consensus scalability not

      benchmarked

      [5]

      Hybrid fog- edge for real- time

      monitoring

      Localised processing

      Fog layer latency reduction

      x

      x

      x

      Synthetic IoMT traffic data

      Sy

      Fog vs. latency trade-off

      unquantified

      [8]

      Hybrid federated SVM + trust

      management

      Trust-score- gated participation

      Lightweight SVM; power objective

      P

      P

      P

      Simulation; no clinical dataset

      Si

      No physical hardware energy

      measure

      [22]

      Lightweight authentication for IoMT

      Auth. protocol limits ID

      exposure

      WBAN

      communication overhead minimised

      x

      Y

      x

      Synthetic WBAN

      scenario data

      Sy

      Isolated from FL training pipeline

      [10]

      Blockchain- enhanced FL (survey)

      DP +

      blockchain aggregation (survey)

      Not benchmarked

      x

      x

      x

      No empirical evaluation

      N

      Survey only; no empirical framework

      [2]

      FED-EHR

      decentralised analytics

      Federated training; no

      noise injection

      Wearable- sensor targets;

      no compression

      x

      x

      x

      Real EHR- linked

      wearable sensor data

      R

      Lightweight not a primary objective

      [9]

      Adaptive blockchain + RL consensus

      Blockchain update integrity

      RL-based resource forecasting

      x

      P

      x

      Simulated IoMT

      network

      Si

      Evaluated on simulation not hardware

      [24]

      CNN-GRU +

      differential privacy

      DP on federated aggregation step

      CNN-GRU

      sized for telemedicine

      P

      P

      x

      PhysioNet MIT-BIH; MIMIC-III

      R

      e-value not stated; no energy measure

      [11]

      Quantum- enhanced federated

      blockchain

      Multi-chain

      + adaptive consensus

      Dynamic relational learning

      x

      x

      x

      Multi-modal cardiovascular data

      R

      Quantum overhead not characterised

      MS = model size reduction; CC = communication cost reduction; EC = energy consumption reduction. Y = fully addressed; P = partial; x = not addressed.

    4. PrivacyAccuracy Trade-off Analysis

    Table IV and Fig. 4 consolidate privacyaccuracy reporting across all 28 studies. Key findings: (i) only [24] reports any diagnostic accuracy alongside a DP mechanism, and even there the value is not stated; (ii) no study reports AUC, sensitivity, and specificity jointly with an explicit ; (iii) most privacy mechanisms (blockchain, trust-gating, secure aggregation) have no tunable , making cross-study comparison impossible.

    Fig. 4. Privacyaccuracy reporting gap across 28 included studies.

    TABLE IV

    PRIVACYACCURACY TRADE-OFF SUMMARY (SELECTED STUDIES)

    Ref.

    Privacy Mechanism

    e Value

    AUC

    Sensitivity

    Specificity

    Overall Acc.

    Status

    [24]

    DP on CNN- GRU

    aggregation

    NR

    NR

    NR

    NR

    ~95% (1 pt)

    Incomplete: e and full metrics

    missing

    [2] Federated training (no

    DP)

    N/A

    NR

    NR

    NR

    NR

    Gap: no clinical accuracy reported

    [8]

    Trust-score gating (non- DP)

    N/A

    NR

    NR

    NR

    Power metrics only

    Gap: no clinical accuracy

    [3]

    Blockchain

    RL (no DP)

    N/A

    NR

    NR

    NR

    Risk score only

    Gap: no accuracy

    metrics

    [17]

    DP survey (conceptual)

    Multiple

    NR

    NR

    NR

    NR

    Conceptual only

    [10]

    DP +

    blockchain (survey)

    NR

    NR

    NR

    NR

    NR

    Conceptual only

    [12]-[16]

    FL intrusion detection

    N/A

    Detection AUC

    NR

    NR

    Detection accuracy

    Not clinical diagnostic accuracy

    Recommended reporting protocol: Future studies should state (a) explicit value; (b) AUC, sensitivity, specificity; (c) metrics at {0.1, 1.0, 10.0}; (d) noise scale calibration method.

  4. SUMMARY FINDINGS

    TABLE V

    STRENGTHS AND WEAKNESSES ACROSS THE REVIEWED CORPUS

    ID

    Theme

    Finding

    S1

    Privacy-mechanism diversity

    DP, secure aggregation, blockchain, and trust-gating each

    independently validated across multiple studies [8,10,17,19,20].

    S2

    Rapid growth

    14 of 28 studies (50%) published in 2025 alone; field is accelerating.

    S3

    Cross-domain base

    Corpus spans federated optimisation, blockchain, CNN-GRU, and

    lightweight cryptography [22,24].

    S4

    Clinical validation (subset)

    [24] uses PhysioNet MIT-BIH and MIMIC-III; [2] uses real EHR

    data.

    W1

    Lightweight inconsistency

    7 of 10 frameworks score (MS x, CC x, EC x)-efficiency via offloading only (Table III).

    W2

    No hardware energy benchmarking

    No study measures EC on physical microcontroller or wearable

    hardware.

    W3

    Privacyutility unreported

    Only [24] links accuracy to DP; no study reports AUC/Sens/Spec

    with stated (Table IV).

    W4

    Blockchain overhead uncharacterised

    No study reports latency, energy, or bandwidth added by consensus

    on constrained clients [3,9,11].

    W5

    Fragmentation

    Authentication [22], IDS [13,15], aggregation [19] addressed in

    isolation, not integrated.

  5. RESEARCH GAP ANALYSIS

    TABLE VI RESEARCH GAP ANALYSIS

    Dimension

    Gap Description

    Evidence

    Severity

    Model efficiency

    No study benchmarks model compression on physical

    constrained IoHT hardware using MS/CC/EC criteria

    [8],[22],[9],[24]

    Critical

    Validation realism

    Most use simulated or single-domain datasets; see Table

    III validation column

    [2],[24],[11]

    Critical

    Privacyutility trade-off

    No study reports AUC, Sens., Spec. across multiple

    values (Table IV)

    [17],[19],[24]

    Critical

    Overhead accounting

    Blockchain consensus/IDS not benchmarked for energy,

    latency, bandwidth on constrained clients

    [3],[13],[9]

    High

    Integration

    Auth., IDS, aggregation, and lightweight design treated as

    isolated sub-problems

    [19],[22],[16]

    High

    Standardisation

    No shared benchmark suite or resource-cost reporting

    format for RPM FL comparison

    All 28 studies

    High

    Adaptive client mgmt.

    Client selection and personalisation for heterogeneous

    wearables underexplored

    [26],[8]

    Moderate

    Regulatory alignment

    Few studies map privacy mechanisms onto HIPAA or

    GDPR requirements

    [18],[20]

    Moderate

  6. PROPOSED LIGHTWEIGHT FRAMEWORK

    1. Architecture Overview

      Drawing on the gap analysis, a practically deployable framework requires four components currently appearing in isolation across the corpus (Fig. 5): (1) Compressed client models-INT8 quantised or pruned architectures sized for wearable hardware; (2) Tunable differential privacy-calibrated noise with explicit and accuracy reporting at multiple budget levels; (3) Lightweight integrity protection-trust-score gating without full blockchain consensus overhead; (4) Realistic hardware validation-energy and latency benchmarking on physical constrained platforms using PhysioNet MIT-BIH or MIMIC-III.

    2. Algorithm

      Algorithm 1 presents pseudocode showing how all four components interact within one training round, making their data-flow dependencies explicit for the first time in this corpus. The compressed model (C1) determines gradient magnitude that DP (C2) must clip and perturb. Trust-score gating (C3) filters the resulting DP-gradients. Validation (C4) evaluates AUC/sensitivity/specificity per round on a standardised clinical dataset, closing the privacyaccuracy feedback loop.

      Algorithm 1: Lightweight Privacy-Preserving Federated Learning for Remote Patient Monitoring (RPM)

      Input:

      N : Number of clients

      M0 : Initial compressed global model , , C : Differential Privacy parameters r : Compression ratio

      : Trust threshold

      T : Number of communication rounds E : Number of local training epochs

      Output:

      MT : Trained lightweight global model Initialize

      1. Compute DP noise scale:

        C Ă— (2 Ă— ln(1.25 / )) /

      2. Initialize trust score for each client:

        i 0.5 for i = 1 to N

      3. Deploy compressed model M0 to all clients. For each communication round t = 1 to T do Server (Interity Module)

      4. Select trusted clients:

        St { i | i }

      5. Broadcast global model M(t1) to all clients in St. Client-Side Training (Compressed Model)

      6. For each client i St do

        Load compressed model M(t1). Train locally using SGD for E epochs:

        Mi(t) LocalSGD(M(t1), Di, E) Compute local update:

        Mi Mi(t) M(t1) Client-Side Differential Privacy

      7. Clip the model update:

        Mi Mi Ă— min(1, C / ||Mi||)

      8. Add Gaussian noise:

        MiDP Mi + N(0, ²C²I)

      9. Send MiDP to the server.

      10. Log client resource usage:

        Energy Ei (mJ)

        Latency Li (ms)

        Server Aggregation and Integrity Verification

      11. Update trust score:

        i TrustUpdate(i, MiDP)

      12. Re-filter trusted clients:

        St* { i | i }

      13. Aggregate model updates:

        Mt M(t1) + (1 / |St*|) Ă— MiDP

      14. Requantize Mt to maintain compressed representation. Model Validation

      15. Evaluate Mt on PhysioNet / MIMIC-III holdout dataset.

    6. Report:

    • AUC

    • Sensitivity

    • Specificity

    • Average Energy Consumption (mJ) End For

    Return

    17. Return final global model MT.

  7. FUTURE WORK

    Four priority directions emerge from Table VI. First, hardware-realistic benchmarking on physical microcontroller-class platforms (e.g., ARM Cortex-M) with standardised energy and latency measurement must accompany every future accuracy result. Second, privacyutility curves reporting AUC, sensitivity, and specificity at {0.1, 1.0, 10.0} should become the community standard for DP-enhanced RPM frameworks. Third, a unified benchmark suite-combining non-IID splits of PhysioNet MIT-BIH or MIMIC-III with a defined resource-cost reporting format-would enable the first reproducible cross-study comparison. Fourth, adaptive client selection and personalisation strategies for heterogeneous wearable fleets warrant investigation, extending the trust- management work of [8] to hardware-realistic settings.

  8. CONCLUSION

This systematic review synthesised 28 studies (20222026) on lightweight, privacy-preserving FL for remote patient monitoring. A formal three-dimensional lightweight definition (MS, CC, EC) applied to Table III reveals that 7 of 10 representative frameworks achieve efficiency only through network offloading, satisfying none of the three criteria. A new privacyaccuracy trade- off analysis shows that no study reports AUC, sensitivity, and specificity alongside an explicit , identifying a critical gap for clinical deployment. The proposed four-component architecture (Fig. 5, Algorithm 1) integrates compressed client models, tunable

differential privacy, lightweight integrity protection, and hardware-realistic validation in a single measured pipeline-a configuration no reviewed study implements end-to-end. Implementing and benchmarking this pipeline on physical constrained hardware against PhysioNet MIT-BIH and MIMIC-III is identified as the fields most impactful next step.

.REFERENCES

  1. P. He, D. Huang, D. Wu et al., A survey of Internet of medical things: technology, application and future directions, Digital Commun. Netw., vol. 12, no. 5,

    pp. 717742, 2026.

  2. R. U. Z. Wani and O. Can, FED-EHR: A Privacy-Preserving Federated Learning Framework for Decentralized Healthcare Analytics, Electronics, vol. 14, no. 16, pp. 3261, 2025.

  3. C. Dhasaratha, M. K. Hasan, S. Islam et al., Data privacy model using blockchain reinforcement federated learning for scalable IoMT, CAAI Trans. Intell. Technol., 2024.

  4. S. Punitha and K. S. Preetha, Enhancing reliability and security in cloud-based telesurgery using swarm-evoked distributed FL, Sci. Rep., vol. 15, pp. 27226, 2025.

  5. U. Islam et al., A hybrid fog-edge computing architecture for real-time health monitoring in IoMT, Sci. Rep., vol. 15, pp. 25655, 2025.

  6. D. Sirohi et al., Federated learning for 6G-enabled secure communication systems: a comprehensive survey, Artif. Intell. Rev., vol. 56, pp. 1129711389, 2023.

  7. N. Nezhadsistani, N. S. Moayedian, and B. Stiller, Blockchain-Enabled Federated Learning in Healthcare: Survey and State-of-the-Art, IEEE Access, vol. 13, pp. 119922119945, 2025.

  8. S. Khan et al., An Expert Hybrid Federated Learning and Trust Management for Security, Efficiency, and Power Optimization in Smart Health, IEEE Access, vol. 13, pp. 5819158210, 2025.

  9. C. V. N. U. B. Murthy and M. L. Shri, An Adaptive Blockchain Framework for Federated IoMT with RL-Based Consensus, Sci. Rep., vol. 16, pp. 8296, 2026.

  10. Z. N. Limbepe, K. Gai, and J. Yu, Blockchain-Based Privacy-Enhancing Federated Learning in Smart Healthcare: A Survey, Blockchains, vol. 3, no. 1, pp. 1, 2025.

  11. R. Sivakami et al., Quantum-enhanced federated blockchain for privacy-preserving cardiovascular intelligence, Sci. Rep., 2026.

  12. S. A. Alzakari et al., Converging Technologies for Health Prediction and Intrusion Detection in IoHT, IEEE Access, vol. 12, pp. 9946999498, 2024.

  13. R. Bensaid et al., SA-FLIDS: Secure and Authenticated FL-Based Intelligent Network IDS for Smart Healthcare, PeerJ Comput. Sci., vol. 10, e2414, 2024.

  14. S. R. Hassan et al., A comprehensive survey on intrusion detection in IoMT, ICT Express, vol. 11, no. 6, pp. 12911310, 2025.

  15. F. S. Alrayes et al., Hybrid Cross-Temporal Contrastive Model with Spiking Energy-Efficient IDS in IOMT, Int. J. Comput. Intell. Syst., vol. 18, pp. 270, 2025.

  16. A. Daulay et al., Novel Federated Graph Contrastive Learning for IoMT Security, Mathematics, vol. 13, pp. 2471, 2025.

  17. X. Gu, F. Sabrina, Z. Fan, and S. Sohail, A Review of Privacy Enhancement Methods for FL in Healthcare, Int. J. Environ. Res. Public Health, vol. 20, pp. 6539, 2023.

  18. N. Khalid et al., Privacy-preserving artificial intelligence in healthcare: Techniques and applications, Comput. Biol. Med., vol. 158, pp. 106848, 2023.

  19. M. Aggarwal et al., A Survey on Privacy-Preserving Healthcare Services Focusing on Robust Aggregation, Int. J. Comput. Intell. Syst., vol. 18, pp. 326, 2025.

  20. K. Li et al., Privacy preservation in blockchain-based healthcare data sharing, Peer-to-Peer Netw. Appl., vol. 18, pp. 302, 2025.

  21. A. Singh and K. Chatterjee, Edge computing based secure health monitoring framework for electronic healthcare, Cluster Comput., vol. 26, pp. 12051220, 2022.

  22. A. Merchant et al., An efficient lightweight authentication scheme for smart healthcare in IoMT, Discov. Comput., vol. 28, pp. 261, 2025.

  23. Y. Chen and C. Lin, Application of Edge Computing IoT Architecture in Community Care Service Systems, Eng. Technol. J., vol. 10, pp. 56685683, 2025.

  24. N. Naik et al., Design and optimisation of an IoT-based AI framework for real-time health monioring and telemedicine diagnostics, Discov. Internet Things, vol. 6, pp. 37, 2026.

  25. R. Ahmad et al., Digital-care in next generation networks: Requirements and future directions, Comput. Netw., vol. 224, pp. 109599, 2023.

  26. E. Zeydan, S. S. Arslan, and M. Liyanage, Managing Distributed ML Lifecycle for Healthcare Data in the Cloud, IEEE Access, vol. 12, pp. 115750115774, 2024.

  27. Federated Learning Applications in the Industrial Internet of Everything (IoE), Stud. Syst. Decis. Control, vol. 611, 2025.

  28. The Convergence of Federated Learning and Healthcare 5.0 and Beyond, Stud. Comput. Intell., vol. 1247, 2026.

  29. H. B. McMahan, E. Moore, D. Ramage, S. Hampson, and B. AgĂĽera y Arcas, Communication-Efficient Learning of Deep Networks from Decentralized Data, Proc. AISTATS, vol. 54, pp. 12731282, 2017.

  30. P. Kairouz et al., Advances and Open Problems in Federated Learning, Found. Trends Mach. Learn., vol. 14, no. 12, pp. 1210, 2021.

  31. N. Rieke et al., The future of digital health with federated learning, NPJ Digit. Med., vol. 3, pp. 119, 2020.

  32. T. Li, A. K. Sahu, A. Talwalkar, and V. Smith, Federated Learning: Challenges, Methods, and Future Directions, IEEE Signal Process. Mag., vol. 37, no. 3,

    pp. 5060, 2020.

  33. M. J. Page et al., The PRISMA 2020 statement: an updated guideline for reporting systematic reviews, BMJ, vol. 372, pp. n71, 2021.