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Effect of Pore Size on the Density of Matrices Made from Collagen Nanofibrils


Effect of Pore Size on the Density of Matrices Made from Collagen Nanofibrils
Authors : Gennaro J. Maffia, Amanda E. Peterman, Jane Alawi
Publication Date: 01-09-2017

Authors

Author(s):  Gennaro J. Maffia, Amanda E. Peterman, Jane Alawi

Published in:   International Journal of Engineering Research & Technology

License:  This work is licensed under a Creative Commons Attribution 4.0 International License.

Website: www.ijert.org

Volume/Issue:   Volume. 6 - Issue. 08 , August - 2017

e-ISSN:   2278-0181

Abstract

Type I bovine collagen matrices are used for a variety of applications in biomedical engineering and environmental engineering. They are produced from collagen nanofibrils using a multi-step process involving freezing, thermal soaking, freeze-drying and crosslinking of collagen dispersions. The resulting product can be of a variety of geometries and morphologies, but typically maintains the volume of the original dispersion of collagen nanofibrils. There is minimal shrinkage expected during the drying and crosslinking. The density of the final collagen matrix is the mass of the original formulation, minus the liquids, divided by the volume of the formulation; which was verified with measurements. In this research, it was discovered that the matrix density is not a function of pore size or processing specifics, such as thermal soaking time. The density of the collagen matrix was studied as a function of thermal soaking times, which controls the pore size of the matrix. Matrices starting with a formulation by parts (w) of collagen/acid/water equal to 1/5/94 produced a matrix with a density of 13.4 g/l. This is an important discovery in the manufacture of matrices with controllable pore size and morphology to accommodate the specific cell size being grown.

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